37 research outputs found

    Architecture d'interopérabilité et mécanismes de relève pour les réseaux sans fil de prochaine génération

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    Intégration, interopéribilité et mobilité -- An analytical framework for performance evaluation of IPV6-Based mobility management protocols -- An architecture for seamless mobility support in Ip-Based next generation wireless networks -- Adaptive handoff scheme for heterogeneous ip wireless networks -- Enhanced fast handoff scheme for heterogeneous wireless networks

    Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

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    Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

    An interworking architecture for heterogeneous IP wireless networks

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    Reliable Integrated Architecture for Heterogeneous Mobile and Wireless Networks

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    Abstract — The major trend in next-generation or 4G wireless networks (NGWN/4G) is the coexistence of diverse but complementary architectures and wireless access technologies. In this context, an appropriate integration and interworking of existing wireless networks are crucial to allow seamless roaming across those networks. Several integrated architectures have been proposed for 3G cellular networks and wireless local area networks (WLANs) by both third generation wireless initiatives, 3GPP and 3GPP2. However, the proposed architectures have several drawbacks, the most significant being the absence of quality of service (QoS) guarantees, seamless roaming and service continuity. This paper proposes a novel architecture, called Integrated InterSystem Architecture (IISA), which enables the integration and interworking of various wireless networks and hide their heterogeneities from one another. The IISA architecture aims provisioning of guaranteed seamless roaming and service continuity across different access networks. Performance evaluation shows that IISA together with the proposed handoff management scheme provide significant gains than existing interworking architectures and mobility management protocols. Index Terms — Interworking architecture, seamless roaming, mobility management, quality of service

    Emerging wireless networks: concepts, techniques and applications

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    An authoritative collection of research papers and surveys, Emerging Wireless Networks: Concepts, Techniques, and Applications explores recent developments in next-generation wireless networks (NGWNs) and mobile broadband networks technologies, including 4G (LTE, WiMAX), 3G (UMTS, HSPA), WiFi, mobile ad hoc networks, mesh networks, and wireless sensor networks. Focusing on improving the performance of wireless networks and provisioning better quality of service and quality of experience for users, it reports on the standards of different emerging wireless networks, applications, and service f

    Efficient Handoff Scheme for Heterogeneous IPv6-based Wireless Networks

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